EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.23.38 | Iva-Val-Val-Sta-Ala-Sta | - |
Plasmodium falciparum | |
3.4.23.38 | Ro40-4388 | - |
Plasmodium falciparum | |
3.4.23.38 | Ro40-5576 | - |
Plasmodium falciparum | |
3.4.23.39 | Iva-Val-Val-Sta-Ala-Sta | - |
Plasmodium falciparum | |
3.4.23.39 | Ro40-4388 | - |
Plasmodium falciparum | |
3.4.23.39 | Ro40-5576 | - |
Plasmodium falciparum |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.23.38 | 0.005 | - |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.38 | 0.005 | - |
Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.38 | 0.006 | - |
Lys-Pro-Ile-Lys-Phe-Phe(NO2)-Arg-Leu | pH 4.4, 37°C, naturally occuring enzyme | Plasmodium falciparum | |
3.4.23.38 | 0.006 | - |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys | pH 4.4, 37°C, naturally occuring | Plasmodium falciparum | |
3.4.23.38 | 0.008 | - |
Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe | pH 4.4, 37°C, naturally occuring enzyme | Plasmodium falciparum | |
3.4.23.38 | 0.01 | - |
Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.38 | 0.01 | - |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.38 | 0.01 | - |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, naturally occuring enzyme | Plasmodium falciparum | |
3.4.23.38 | 0.015 | - |
Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, naturally occuring enzyme | Plasmodium falciparum | |
3.4.23.38 | 0.02 | - |
Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.39 | 0.006 | - |
Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.39 | 0.006 | - |
Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe | pH 4.4, 37°C, naturally occuring enzyme | Plasmodium falciparum | |
3.4.23.39 | 0.007 | - |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, naturally occuring enzyme or recombinant enzyme | Plasmodium falciparum | |
3.4.23.39 | 0.008 | - |
Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, naturally occuring enzyme | Plasmodium falciparum | |
3.4.23.39 | 0.01 | - |
Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.39 | 0.01 | - |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.23.38 | Plasmodium falciparum | - |
- |
- |
3.4.23.39 | Plasmodium falciparum | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.23.38 | Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe + H2O | - |
Plasmodium falciparum | Leu-Glu-Arg-Ile-Phe + Phe(NO2)-Ser-Phe | - |
? | |
3.4.23.38 | Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys + H2O | - |
Plasmodium falciparum | Lys-Glu-Leu-Val-Phe + Phe(NO2)-Ala-Leu-Lys | - |
? | |
3.4.23.38 | Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys + H2O | - |
Plasmodium falciparum | Lys-Glu-Phe-Asn-Phe + Phe(NO2)-Ala-Leu-Lys | - |
? | |
3.4.23.38 | Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys + H2O | - |
Plasmodium falciparum | Lys-Glu-Phe-Val-Phe + Phe(NO2)-Ala-Leu-Lys | - |
? | |
3.4.23.38 | Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys + H2O | - |
Plasmodium falciparum | Lys-Glu-Phe-Val-Phe + Phe(NO2)-Arg-Leu-Lys | - |
? | |
3.4.23.38 | Lys-Pro-Ile-Lys-Phe-Phe(NO2)-Arg-Leu + H2O | - |
Plasmodium falciparum | Lys-Pro-Ile-Lys-Phe + Phe(NO2)-Arg-Leu | - |
? | |
3.4.23.39 | Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe + H2O | - |
Plasmodium falciparum | Leu-Glu-Arg-Ile-Phe + Phe(NO2)-Ser-Phe | - |
? | |
3.4.23.39 | Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys + H2O | - |
Plasmodium falciparum | Lys-Glu-Leu-Val-Phe + Phe(NO2)-Ala-Leu-Lys | - |
? | |
3.4.23.39 | Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys + H2O | - |
Plasmodium falciparum | Lys-Glu-Phe-Asn-Phe + Phe(NO2)-Ala-Leu-Lys | - |
? | |
3.4.23.39 | Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys + H2O | - |
Plasmodium falciparum | Lys-Glu-Phe-Val-Phe + Phe(NO2)-Ala-Leu-Lys | - |
? | |
3.4.23.39 | Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys + H2O | - |
Plasmodium falciparum | Lys-Glu-Phe-Val-Phe + Phe(NO2)-Arg-Leu-Lys | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.23.38 | 1.6 | - |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.38 | 2 | - |
Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.38 | 2.1 | - |
Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.38 | 3.5 | - |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.38 | 10 | - |
Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.38 | 10 | - |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys | pH 4.4, 37°C, naturally occuring enzyme | Plasmodium falciparum | |
3.4.23.38 | 12 | - |
Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, naturally occuring enzyme | Plasmodium falciparum | |
3.4.23.38 | 16 | - |
Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe | pH 4.4, 37°C, naturally occuring enzyme | Plasmodium falciparum | |
3.4.23.38 | 18 | - |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, naturally occuring enzyme | Plasmodium falciparum | |
3.4.23.39 | 1.5 | - |
Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.39 | 6 | - |
Lys-Glu-Leu-Val-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, naturally occuring enzyme | Plasmodium falciparum | |
3.4.23.39 | 7 | - |
Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.39 | 10 | - |
Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe | pH 4.4, 37°C, naturally occuring enzyme | Plasmodium falciparum | |
3.4.23.39 | 11 | - |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.39 | 13 | - |
Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.39 | 17 | - |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.39 | 19 | - |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C, naturally occuring enzyme | Plasmodium falciparum |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.23.38 | 0.0000005 | - |
Iva-Val-Val-Sta-Ala-Sta | pH 4.4, 37°C, naturally occuring enzyme | Plasmodium falciparum | |
3.4.23.38 | 0.0000007 | - |
Iva-Val-Val-Sta-Ala-Sta | pH 4.4, 37°C, recombinant enzyme | Plasmodium falciparum | |
3.4.23.38 | 0.000004 | - |
Ro40-4388 | pH 4.4, 37°C | Plasmodium falciparum | |
3.4.23.38 | 0.000006 | - |
Ro40-5576 | - |
Plasmodium falciparum | |
3.4.23.38 | 0.000009 | - |
Ro40-4388 | naturally occuring enzyme | Plasmodium falciparum | |
3.4.23.39 | additional information | - |
additional information | Ki value for Iva-Val-Val-Sta-Ala-Sta is below 0.1 nM | Plasmodium falciparum | |
3.4.23.39 | 0.00025 | - |
Ro40-5576 | - |
Plasmodium falciparum | |
3.4.23.39 | 0.0005 | - |
Ro40-4388 | pH 4.4, 37°C | Plasmodium falciparum |